Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC4598846 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Sun Yi Y Sheng Zhen Z Ma Chao C Tang Kailin K Zhu Ruixin R Wu Zhuanbin Z Shen Ruling R Feng Jun J Wu Dingfeng D Huang Danyi D Huang Dandan D Fei Jian J Liu Qi Q Cao Zhiwei Z
Nature communications 20150928
The identification of synergistic chemotherapeutic agents from a large pool of candidates is highly challenging. Here, we present a Ranking-system of Anti-Cancer Synergy (RACS) that combines features of targeting networks and transcriptomic profiles, and validate it on three types of cancer. Using data on human β-cell lymphoma from the Dialogue for Reverse Engineering Assessments and Methods consortium we show a probability concordance of 0.78 compared with 0.61 obtained with the previous best a ...[more]