Ontology highlight
ABSTRACT:
SUBMITTER: Veronese M
PROVIDER: S-EPMC4635232 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Veronese Mattia M Bodini Benedetta B García-Lorenzo Daniel D Battaglini Marco M Bongarzone Salvatore S Comtat Claude C Bottlaender Michel M Stankoff Bruno B Turkheimer Federico E FE
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150610 11
An accurate in vivo measure of myelin content is essential to deepen our insight into the mechanisms underlying demyelinating and dysmyelinating neurological disorders, and to evaluate the effects of emerging remyelinating treatments. Recently [(11)C]PIB, a positron emission tomography (PET) tracer originally conceived as a beta-amyloid marker, has been shown to be sensitive to myelin changes in preclinical models and humans. In this work, we propose a reference-region methodology for the voxelw ...[more]