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Targeting STING pathways for the treatment of cancer.

ABSTRACT: Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

SUBMITTER: Gravekamp C 

PROVIDER: S-EPMC4635943 | biostudies-other | 2015 Dec

REPOSITORIES: biostudies-other

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