Ontology highlight
ABSTRACT:
SUBMITTER: Rutherford ST
PROVIDER: S-EPMC4640798 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Rutherford Steven T ST Valastyan Julie S JS Taillefumier Thibaud T Wingreen Ned S NS Bassler Bonnie L BL
Proceedings of the National Academy of Sciences of the United States of America 20151019 44
Five homologous noncoding small RNAs (sRNAs), called the Qrr1-5 sRNAs, function in the Vibrio harveyi quorum-sensing cascade to drive its operation. Qrr1-5 use four different regulatory mechanisms to control the expression of ∼ 20 mRNA targets. Little is known about the roles individual nucleotides play in mRNA target selection, in determining regulatory mechanism, or in defining Qrr potency and dynamics of target regulation. To identify the nucleotides vital for Qrr function, we developed a met ...[more]