Ontology highlight
ABSTRACT:
SUBMITTER: Hakes DJ
PROVIDER: S-EPMC46437 | biostudies-other | 1993 May
REPOSITORIES: biostudies-other
Hakes D J DJ Martell K J KJ Zhao W G WG Massung R F RF Esposito J J JJ Dixon J E JE
Proceedings of the National Academy of Sciences of the United States of America 19930501 9
The vaccinia virus VH1 gene product is a dual specificity protein phosphatase with activity against both phosphoserine- and phosphotyrosine-containing substrates. We investigated the potential presence of VH1 analogs in other viruses. Hybridization and sequence data indicated that a phosphatase related to the VH1 phosphatase is highly conserved in the genomes of smallpox variola virus and other orthopoxviruses. The open reading frames from the raccoonpox virus and the smallpox variola virus Bang ...[more]