Ontology highlight
ABSTRACT:
SUBMITTER: Hardin JW
PROVIDER: S-EPMC4678811 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Nucleic acids research 20151025 22
In large ribonucleoprotein machines, such as ribosomes and spliceosomes, RNA functions as an assembly scaffold as well as a critical catalytic component. Protein binding to the RNA scaffold can induce structural changes, which in turn modulate subsequent binding of other components. The spliceosomal U4/U6 di-snRNP contains extensively base paired U4 and U6 snRNAs, Snu13, Prp31, Prp3 and Prp4, seven Sm and seven LSm proteins. We have studied successive binding of all protein components to the snR ...[more]