Ontology highlight
ABSTRACT:
SUBMITTER: Zhai Z
PROVIDER: S-EPMC4703904 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Zhai Zongzhao Z Kondo Shu S Ha Nati N Boquete Jean-Philippe JP Brunner Michael M Ueda Ryu R Lemaitre Bruno B
Nature communications 20151222
Stem cell self-renewal and differentiation are coordinated to maintain tissue homeostasis and prevent cancer. Mutations causing stem cell proliferation are traditionally the focus of cancer studies. However, the contribution of the differentiating stem cell progenies in tumorigenesis is poorly characterized. Here we report that loss of the SOX transcription factor, Sox21a, blocks the differentiation programme of enteroblast (EB), the intestinal stem cell progeny in the adult Drosophila midgut. T ...[more]