Unknown

Dataset Information

0

Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture.


ABSTRACT: Extracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-β1). In tendon tissue repair, increased activity of TGF-β1 leads to progressive fibrosis. Decorin (DCN) and interleukin 10 (IL-10) antagonise pathological collagen synthesis by exerting a neutralising effect via downregulation of TGF-β1. Herein, we report that the delivery of DCN and IL-10 transgenes from a collagen hydrogel system supresses the constitutive expression of TGF-β1 and a range of pro-fibrotic extracellular matrix genes.

SUBMITTER: Abbah SA 

PROVIDER: S-EPMC4748261 | biostudies-other | 2016 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6284330 | biostudies-literature
2024-03-15 | GSE252958 | GEO
| S-EPMC8922653 | biostudies-literature
| S-EPMC3971953 | biostudies-literature
| S-EPMC5524343 | biostudies-literature
| S-EPMC6892632 | biostudies-literature
| S-EPMC5575302 | biostudies-literature
| S-EPMC6527347 | biostudies-literature
| S-EPMC11361265 | biostudies-literature
| S-EPMC9673102 | biostudies-literature