The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity.
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ABSTRACT: We have shown that melanoma-derived factors alter the function of differentiated tissue-resident dendritic cells (DC) in a tumorigenicity-dependent manner. Soluble factors, including TGFβ1 and VEGF-A, contributed to dendritic cell dysfunction associated with a highly-aggressive melanoma and conferred a phenotype upon DC likely to favor immune escape and tumor outgrowth.
SUBMITTER: Hargadon KM
PROVIDER: S-EPMC4760289 | biostudies-other | 2016
REPOSITORIES: biostudies-other
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