Ontology highlight
ABSTRACT:
SUBMITTER: Van Engelenburg SB
PROVIDER: S-EPMC4791044 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Van Engelenburg Schuyler B SB Shtengel Gleb G Sengupta Prabuddha P Waki Kayoko K Jarnik Michal M Ablan Sherimay D SD Freed Eric O EO Hess Harald F HF Lippincott-Schwartz Jennifer J
Science (New York, N.Y.) 20140116 6171
The human immunodeficiency virus (HIV) hijacks the endosomal sorting complexes required for transport (ESCRT) to mediate virus release from infected cells. The nanoscale organization of ESCRT machinery necessary for mediating viral abscission is unclear. Here, we applied three-dimensional superresolution microscopy and correlative electron microscopy to delineate the organization of ESCRT components at HIV assembly sites. We observed ESCRT subunits localized within the head of budding virions an ...[more]