Effective induction of high-titer antibodies by viral vector vaccines.
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ABSTRACT:
SUBMITTER: Draper SJ
PROVIDER: S-EPMC4822545 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Publications
Effective induction of high-titer antibodies by viral vector vaccines.
Draper Simon J SJ Moore Anne C AC Goodman Anna L AL Long Carole A CA Holder Anthony A AA Gilbert Sarah C SC Hill Fergal F Hill Adrian V S AV
Nature medicine 20080727 8
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effectiv ...[more]
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