Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC4825054 | biostudies-other | 2015 Aug
REPOSITORIES: biostudies-other
Zhang Sufeng S Ermann Joerg J Succi Marc D MD Zhou Allen A Hamilton Matthew J MJ Cao Bonnie B Korzenik Joshua R JR Glickman Jonathan N JN Vemula Praveen K PK Glimcher Laurie H LH Traverso Giovanni G Langer Robert R Karp Jeffrey M JM
Science translational medicine 20150801 300
There is a clinical need for new, more effective treatments for chronic and debilitating inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Targeting drugs selectively to the inflamed intestine may improve therapeutic outcomes and minimize systemic toxicity. We report the development of an inflammation-targeting hydrogel (IT-hydrogel) that acts as a drug delivery system to the inflamed colon. Hydrogel microfibers were generated from ascorbyl palmitate, an amphiph ...[more]