Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lactic acid polarizes macrophages to a tumor-promoting state.

ABSTRACT: Tumor-associated macrophages have been associated with a poor prognosis in most types of tumors. However, tumor-derived signals that activate macrophages have not been well defined. We review our recent finding that tumor-derived lactic acid is necessary and sufficient to polarize tumor-associated macrophages to a tumor-promoting state.

SUBMITTER: Colegio OR

PROVIDER: S-EPMC4839384 | biostudies-other | 2016 Mar

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-β responses in tumor-associated macrophages.

Project description:Fatty acid-binding proteins (FABP) are known central regulators of both metabolic and inflammatory pathways, but their role in tumor development remains largely unexplored. Here, we report that host expression of epidermal FABP (E-FABP) protects against mammary tumor growth. We find that E-FABP is highly expressed in macrophages, particularly in a specific subset, promoting their antitumor activity. In the tumor stroma, E-FABP-expressing tumor-associated macrophages (TAM) produce high levels of IFN-β through upregulation of lipid droplet formation in response to tumors. E-FABP-mediated IFN-β signaling can further enhance recruitment of tumoricidal effector cells, in particular natural killer cells, to the tumor stroma for antitumor activity. These findings identify E-FABP as a new protective factor to strengthen IFN-β responses against tumor growth.

| S-EPMC4040301 | biostudies-literature

Lactic acid bacteria

Project description:Genome sequencing and assembly: V. lutrae, E. faecium, E. faecalis

| PRJNA833940 | ENA

Lactic Acid Bacteria

Project description:Bacteria associated to human saliva are major microbial components of Ecuadorian indigenous beers (chicha)

| PRJNA311720 | ENA

Lactic acid bacteria

Project description:Isolation and characterization of novel lactic acid bacteria from raw sewage

| PRJNA435410 | ENA

Lactic acid bacteria

Project description:WGS: Florfenicol-resistant lactic acid bacteria from cattle at slaughter

| PRJNA783265 | ENA

Lactic acid bacteria

Project description:studies on metagenomic sequencing of probiotic strains.

| PRJNA992774 | ENA

Lactic acid bacteria

Project description:Whole genome sequencing of lactic acid bacteria

| PRJNA1079298 | ENA

Lactic Acid Bacteria

Project description:Genome sequencing and assembly of Lactic Acid Bacteria from Brazil Northeast region

| PRJNA816552 | ENA

Lactic acid bacteria

Project description:Development of probiotics for inflammatory bowel disease using novel biomarker based screening tool and gnotobiotic mouse model

| PRJNA949423 | ENA

Angiotensin II drives the production of tumor-promoting macrophages.

Project description:Macrophages frequently infiltrate tumors and can enhance cancer growth, yet the origins of the macrophage response are not well understood. Here we address molecular mechanisms of macrophage production in a conditional mouse model of lung adenocarcinoma. We report that overproduction of the peptide hormone Angiotensin II (AngII) in tumor-bearing mice amplifies self-renewing hematopoietic stem cells (HSCs) and macrophage progenitors. The process occurred in the spleen but not the bone marrow, and was independent of hemodynamic changes. The effects of AngII required direct hormone ligation on HSCs, depended on S1P(1) signaling, and allowed the extramedullary tissue to supply new tumor-associated macrophages throughout cancer progression. Conversely, blocking AngII production prevented cancer-induced HSC and macrophage progenitor amplification and thus restrained the macrophage response at its source. These findings indicate that AngII acts upstream of a potent macrophage amplification program and that tumors can remotely exploit the hormone's pathway to stimulate cancer-promoting immunity.

| S-EPMC3582771 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data