Ontology highlight
ABSTRACT:
SUBMITTER: Diebold RJ
PROVIDER: S-EPMC48478 | biostudies-other | 1992 Feb
REPOSITORIES: biostudies-other
Diebold R J RJ Koch W J WJ Ellinor P T PT Wang J J JJ Muthuchamy M M Wieczorek D F DF Schwartz A A
Proceedings of the National Academy of Sciences of the United States of America 19920201 4
Several clones were isolated from a rat genomic library in order to further characterize a region of variability within the third membrane-spanning region of the fourth motif (IVS3) of the L-type voltage-dependent calcium channel. We report here that this diversity arises from alternative splicing of a primary transcript containing a single pair of adjacent exons each encoding a unique sequence for the IVS3 region. Definitive proof of a mutually exclusive splicing mechanism was obtained by genom ...[more]