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Multiple phenotypes in genome-wide genetic mapping studies.


ABSTRACT: For many psychiatric and other traits, diagnoses are based on a number of different criteria or phenotypes. Rather than carrying out genetic analyses on the final diagnosis, it has been suggested that relevant phenotypes should be analyzed directly. We provide an overview of statistical methods for the joint analysis of multiple phenotypes in case-control association studies.

SUBMITTER: Ott J 

PROVIDER: S-EPMC4875235 | biostudies-other | 2011 Jul

REPOSITORIES: biostudies-other

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Multiple phenotypes in genome-wide genetic mapping studies.

Ott Jurg J   Wang Jing J  

Protein & cell 20110606 7


For many psychiatric and other traits, diagnoses are based on a number of different criteria or phenotypes. Rather than carrying out genetic analyses on the final diagnosis, it has been suggested that relevant phenotypes should be analyzed directly. We provide an overview of statistical methods for the joint analysis of multiple phenotypes in case-control association studies. ...[more]

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