Ontology highlight
ABSTRACT:
SUBMITTER: Dejonghe W
PROVIDER: S-EPMC4899852 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Dejonghe Wim W Kuenen Sabine S Mylle Evelien E Vasileva Mina M Keech Olivier O Viotti Corrado C Swerts Jef J Fendrych Matyáš M Ortiz-Morea Fausto Andres FA Mishev Kiril K Delang Simon S Scholl Stefan S Zarza Xavier X Heilmann Mareike M Kourelis Jiorgos J Kasprowicz Jaroslaw J Nguyen Le Son Long le SL Drozdzecki Andrzej A Van Houtte Isabelle I Szatmári Anna-Mária AM Majda Mateusz M Baisa Gary G Bednarek Sebastian York SY Robert Stéphanie S Audenaert Dominique D Testerink Christa C Munnik Teun T Van Damme Daniël D Heilmann Ingo I Schumacher Karin K Winne Johan J Friml Jiří J Verstreken Patrik P Russinova Eugenia E
Nature communications 20160608
ATP production requires the establishment of an electrochemical proton gradient across the inner mitochondrial membrane. Mitochondrial uncouplers dissipate this proton gradient and disrupt numerous cellular processes, including vesicular trafficking, mainly through energy depletion. Here we show that Endosidin9 (ES9), a novel mitochondrial uncoupler, is a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems and that ES9 induces inhibition of CME not because of its effect ...[more]