Ontology highlight
ABSTRACT:
SUBMITTER: Drolet DW
PROVIDER: S-EPMC4900223 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Nucleic acid therapeutics 20160112 3
For any new class of therapeutics, there are certain types of indications that represent a natural fit. For nucleic acid ligands in general, and aptamers in particular, the eye has historically been an attractive site for therapeutic intervention. In this review, we recount the discovery and early development of three aptamers designated for use in ophthalmology, one approved (Macugen), and two in late-stage development (Fovista and Zimura). Every one of these molecules was originally intended f ...[more]