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The retinoblastoma protein: multitasking to suppress tumorigenesis.


ABSTRACT: Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.

SUBMITTER: Vormer TL 

PROVIDER: S-EPMC4905230 | biostudies-other | 2015 Jan-Mar

REPOSITORIES: biostudies-other

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