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Cell-in-cell structures are involved in the competition between cells in human tumors.


ABSTRACT: The engulfment of live cells may represent a mechanism of cell death. We reported that E-cadherin (epithelial cadherin) expression in human cancer cells favors the formation of cell-in-cell structures through the mechanism known as entosis, and that entosis contributes to a form of cellular competition in heterogeneous cancer cell populations.

SUBMITTER: Sun Q 

PROVIDER: S-EPMC4905330 | biostudies-other | 2015 Oct-Dec

REPOSITORIES: biostudies-other

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