Ontology highlight
ABSTRACT:
SUBMITTER: Mencia Castano I
PROVIDER: S-EPMC4906381 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Mencía Castaño Irene I Curtin Caroline M CM Duffy Garry P GP O'Brien Fergal J FJ
Scientific reports 20160614
Bone grafts are the second most transplanted materials worldwide at a global cost to healthcare systems valued over $30 billion every year. The influence of microRNAs in the regenerative capacity of stem cells offers vast therapeutic potential towards bone grafting; however their efficient delivery to the target site remains a major challenge. This study describes how the functionalisation of porous collagen-nanohydroxyapatite (nHA) scaffolds with miR-133a inhibiting complexes, delivered using n ...[more]