Ontology highlight
ABSTRACT:
SUBMITTER: Wei W
PROVIDER: S-EPMC49653 | biostudies-other | 1992 Aug
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19920801 15
The yeast Saccharomyces cerevisiae CDC25 gene encodes a nucleotide-exchange-factor (NEF) that can convert the inactive GDP-bound state of RAS proteins to an active RAS-GTP complex. CDC25 can activate the yeast RAS proteins as well as the human H-ras protein. CDC25 is a member of a family of yeast genes that likely encode NEFs capable of regulating the RAS-related proteins found in yeast. By aligning the amino acid sequence of CDC25-related gene products we found a number of conserved motifs. Usi ...[more]