Ontology highlight
ABSTRACT:
SUBMITTER: Hague BF
PROVIDER: S-EPMC49835 | biostudies-other | 1992 Sep
REPOSITORIES: biostudies-other
Hague B F BF Sawasdikosol S S Brown T J TJ Lee K K Recker D P DP Kindt T J TJ
Proceedings of the National Academy of Sciences of the United States of America 19920901 17
Human CD4 (HuCD4) is the principal receptor for human immunodeficiency virus type 1 (HIV-1) in human cell infection. Susceptibility of rabbit cell lines to infection with HIV-1 raised questions concerning whether a CD4 homolog serves as HIV-1 receptor on rabbit cells. Sequence comparisons of rabbit CD4 (RbCD4) cloned from a rabbit thymus cDNA library showed that 6 of the 18 residues implicated in HIV-1 binding by CD4 differ between the human and rabbit proteins. No correlation between RbCD4 expr ...[more]