Ontology highlight
ABSTRACT:
SUBMITTER: Li XG
PROVIDER: S-EPMC5018871 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Li Xiang-Guo XG Hagert Cecilia C Siitonen Riikka R Virtanen Helena H Sareila Outi O Liljenbäck Heidi H Tuisku Jouni J Knuuti Juhani J Bergman Jörgen J Holmdahl Rikard R Roivainen Anne A
ACS medicinal chemistry letters 20160516 9
Recently mannan from Saccharomyces cerevisiae has been shown to be able to induce psoriasis and psoriatic arthritis in mice, and the phenotypes resemble the corresponding human diseases. To investigate the pathological processes, we set out to label mannan with fluorine-18 ((18)F) and study the (18)F-labeled mannan in vitro and in vivo with positron emission tomography (PET). Accordingly, mannan has been transformed into (18)F-fluoromannan with (18)F-bicyclo[6.1.0]nonyne. In mouse aorta, the bin ...[more]