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Palladium-Catalyzed Oxidative Synthesis of ?-Acetoxylated Enones from Alkynes.

ABSTRACT: We report a palladium-catalyzed oxidative functionalization of alkynes to generate ?-acetoxylated enones in one step. A range of functional groups are well-tolerated in this reaction. Mechanistic studies, including the use of (18) O-labeled DMSO, revealed that the ketone oxygen atom in the product originates from DMSO.

SUBMITTER: Jiang T

PROVIDER: S-EPMC5021131 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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Palladium-Catalyzed Oxidative Synthesis of α-Acetoxylated Enones from Alkynes.

Jiang Tuo T Quan Xu X Zhu Can C Andersson Pher G PG Bäckvall Jan-E JE

Angewandte Chemie (International ed. in English) 20160406 19

We report a palladium-catalyzed oxidative functionalization of alkynes to generate α-acetoxylated enones in one step. A range of functional groups are well-tolerated in this reaction. Mechanistic studies, including the use of (18) O-labeled DMSO, revealed that the ketone oxygen atom in the product originates from DMSO. ...[more]

PMID: 27060476

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