Ontology highlight
ABSTRACT:
SUBMITTER: Asaka MN
PROVIDER: S-EPMC5028886 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Asaka Masamitsu N MN Kawaguchi Atsushi A Sakai Yuri Y Mori Kotaro K Nagata Kyosuke K
Scientific reports 20160920
The organization of nuclear domains is crucial for biological events including virus infection. Newly synthesized influenza viral genome forms viral ribonucleoprotein (vRNP) complexes and is exported from the nucleus to the cytoplasm through a CRM1-dependent pathway mediated by viral proteins M1 and NS2. However, the spatio-temporal regulation of the progeny vRNP in the nucleus is still unclear. Here we found that polycomb repressive complex 2 (PRC2), which contains a methyltransferase subunit E ...[more]