Dataset Information

Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.

ABSTRACT: Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm?Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP), HR = 1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04-1.12) (SBP), HR = 1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82-1.00) and lymphomas: HR = 0.97 (0.93-1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.

SUBMITTER: Christakoudi S

PROVIDER: S-EPMC7115826 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.

Christakoudi Sofia S Kakourou Artemisia A Markozannes Georgios G Tzoulaki Ioanna I Weiderpass Elisabete E Brennan Paul P Gunter Marc M Dahm Christina C CC Overvad Kim K Olsen Anja A Tjønneland Anne A Boutron-Ruault Marie-Christine MC Madika Anne-Laure AL Severi Gianluca G Katzke Verena V Kühn Tilman T Bergmann Manuela M MM Boeing Heiner H Karakatsani Anna A Martimianaki Georgia G Thriskos Paschalis P Masala Giovanna G Sieri Sabina S Panico Salvatore S Tumino Rosario R Ricceri Fulvio F Agudo Antonio A Redondo-Sánchez Daniel D Colorado-Yohar Sandra M SM Mokoroa Olatz O Melander Olle O Stocks Tanja T Häggström Christel C Harlid Sophia S Bueno-de-Mesquita Bas B van Gils Carla H CH Vermeulen Roel C H RCH Khaw Kay-Tee KT Wareham Nicholas J NJ Tong Tammy Y N TYN Freisling Heinz H Johansson Mattias M Lennon Hannah H Aune Dagfinn D Riboli Elio E Trichopoulos Dimitrios D Trichopoulou Antonia A Tsilidis Konstantinos K KK

International journal of cancer 20190820 10

Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recr ...[more]

PMID: 31319002

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Project description:BACKGROUND:The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. OBJECTIVE:We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk. DESIGN:The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95% CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa. RESULTS:Total soft-drink consumption (HR per 100 g/d: 1.03; 95% CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95% CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95% CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake. CONCLUSIONS:Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results.

Dataset Information

Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.

Publications

Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.

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