Ontology highlight
ABSTRACT:
SUBMITTER: Nadal-Nicolas FM
PROVIDER: S-EPMC5144087 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Nadal-Nicolás Francisco M FM Galindo-Romero Caridad C Valiente-Soriano Francisco J FJ Barberà-Cremades María M deTorre-Minguela Carlos C Salinas-Navarro Manuel M Pelegrín Pablo P Agudo-Barriuso Marta M
Scientific reports 20161208
Axonal injury is a common feature of central nervous system insults that culminates with the death of the affected neurons, and an irreversible loss of function. Inflammation is an important component of the neurodegenerative process, where the microglia plays an important role by releasing proinflammatory factors as well as clearing the death neurons by phagocytosis. Here we have identified the purinergic signaling through the P2X7 receptor as an important component for the neuronal death in a ...[more]