Ontology highlight
ABSTRACT:
SUBMITTER: Schaff JC
PROVIDER: S-EPMC5154471 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Schaff James C JC Gao Fei F Li Ye Y Novak Igor L IL Slepchenko Boris M BM
PLoS computational biology 20161213 12
Hybrid deterministic-stochastic methods provide an efficient alternative to a fully stochastic treatment of models which include components with disparate levels of stochasticity. However, general-purpose hybrid solvers for spatially resolved simulations of reaction-diffusion systems are not widely available. Here we describe fundamentals of a general-purpose spatial hybrid method. The method generates realizations of a spatially inhomogeneous hybrid system by appropriately integrating capabilit ...[more]