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Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.

ABSTRACT: In an attempt to define the molecular basis of the functional diversity of K+ channels, we have isolated overlapping rat brain cDNAs that encoded a neuronal delayed rectifier K+ channel, K,4, that is structurally related to the Drosophila Shaw protein. Unlike previously characterized mammalian K+ channel genes, which each contain a single protein-coding exon, K,4 arises from alternative exon usage at a locus that also encodes another mammalian Shaw homolog, NGK2. Thus, the enormous diversity of K+ channels in mammals can be generated not just through gene duplication and divergence but also through alternative splicing of RNA.

SUBMITTER: Luneau CJ

PROVIDER: S-EPMC51567 | biostudies-other | 1991 May

REPOSITORIES: biostudies-other

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Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.

Luneau C J CJ Williams J B JB Marshall J J Levitan E S ES Oliva C C Smith J S JS Antanavage J J Folander K K Stein R B RB Swanson R R

Proceedings of the National Academy of Sciences of the United States of America 19910501 9

In an attempt to define the molecular basis of the functional diversity of K+ channels, we have isolated overlapping rat brain cDNAs that encoded a neuronal delayed rectifier K+ channel, K,4, that is structurally related to the Drosophila Shaw protein. Unlike previously characterized mammalian K+ channel genes, which each contain a single protein-coding exon, K,4 arises from alternative exon usage at a locus that also encodes another mammalian Shaw homolog, NGK2. Thus, the enormous diversity of ...[more]

PMID: 2023941

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