Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC5171816 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Chen Zhenghu Z Wang Long L Yao Dayong D Yang Tianshu T Cao Wen-Ming WM Dou Jun J Pang Jonathan C JC Guan Shan S Zhang Huiyuan H Yu Yang Y Zhao Yanling Y Wang Yongfeng Y Xu Xin X Shi Yan Y Patel Roma R Zhang Hong H Vasudevan Sanjeev A SA Liu Shangfeng S Yang Jianhua J Nuchtern Jed G JG
Scientific reports 20161219
Neuroblastoma (NB) is the most common extracranial tumor in children. Unlike in most adult tumors, tumor suppressor protein 53 (p53) mutations occur with a relatively low frequency in NB and the downstream function of p53 is intact in NB cell lines. Wip1 is a negative regulator of p53 and hindrance of Wip1 activity by novel inhibitor GSK2830371 is a potential strategy to activate p53's tumor suppressing function in NB. Yet, the in vivo efficacy and the possible mechanisms of GSK2830371 in NB hav ...[more]