Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection.

ABSTRACT: ND10 structures are disrupted during herpes simplex virus type 1 (HSV-1) infection by viral regulatory protein ICP0. The significance of this effect remains controversial, partly because of a report that high-level expression of the major ND10 promyelocytic leukemia (PML) protein precludes ND10 disruption yet does not inhibit HSV-1 infection. Here we demonstrate dramatic reorganization of ND10 during HSV-1 infection by live-cell microscopy, even in the presence of overexpressed PML.

SUBMITTER: Everett RD 

PROVIDER: S-EPMC521835 | biostudies-other | 2004 Oct

REPOSITORIES: biostudies-other