Ontology highlight
ABSTRACT:
SUBMITTER: McCall NM
PROVIDER: S-EPMC5240170 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
McCall Nora M NM Kotecki Lydia L Dominguez-Lopez Sergio S Marron Fernandez de Velasco Ezequiel E Carlblom Nicholas N Sharpe Amanda L AL Beckstead Michael J MJ Wickman Kevin K
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20160729 3
The increase in dopamine (DA) neurotransmission stimulated by in vivo cocaine exposure is tempered by G protein-dependent inhibitory feedback mechanisms in DA neurons of the ventral tegmental area (VTA). G protein-gated inwardly rectifying K<sup>+</sup> (GIRK/Kir3) channels mediate the direct inhibitory effect of GABA<sub>B</sub> receptor (GABA<sub>B</sub>R) and D<sub>2</sub> DA receptor (D<sub>2</sub>R) activation in VTA DA neurons. Here we examined the effect of the DA neuron-specific loss of ...[more]