Ontology highlight
ABSTRACT:
SUBMITTER: Yue X
PROVIDER: S-EPMC5303003 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Yue Xuyi X Jin Hongjun H Luo Zonghua Z Liu Hui H Zhang Xiang X McSpadden Ethan D ED Tian Linlin L Flores Hubert P HP Perlmutter Joel S JS Parsons Stanley M SM Tu Zhude Z
Bioorganic & medicinal chemistry 20170116 4
Twelve optically pure enantiomers were obtained using either crystallization or chiral high performance liquid chromatography (HPLC) separation methodologies to resolve six racemic sigma-1 (σ<sub>1</sub>) receptor ligands. The in vitro binding affinities of each enantiomer for σ<sub>1</sub>, σ<sub>2</sub> receptors and vesicular acetylcholine transporter (VAChT) were determined. Out of the 12 optically pure enantiomers, five displayed very high affinities for σ<sub>1</sub> (K<sub>i</sub><2nM) an ...[more]