Ontology highlight
ABSTRACT:
SUBMITTER: Barca-Mayo O
PROVIDER: S-EPMC5309809 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Nature communications 20170210
Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1, are expressed in SCN neurons and in other brain cells, such as astrocytes. However, the role of astrocytic clock genes in controlling rhythmic behaviour is unknown. Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice. Specifically, deletion of astrocytic Bmal1 has an imp ...[more]