Ontology highlight
ABSTRACT:
SUBMITTER: Robichaux WG
PROVIDER: S-EPMC5325072 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Robichaux William G WG Branham-O'Connor Melissa M Hwang Il-Young IY Vural Ali A Kehrl Johne H JH Blumer Joe B JB
The Journal of pharmacology and experimental therapeutics 20170106 3
Activator of G-protein signaling 4 (AGS4)/G-protein signaling modulator 3 (Gpsm3) contains three G-protein regulatory (GPR) motifs, each of which can bind G<i>α</i>i-GDP free of G<i>βγ</i> We previously demonstrated that the AGS4-G<i>α</i>i interaction is regulated by seven transmembrane-spanning receptors (7-TMR), which may reflect direct coupling of the GPR-G<i>α</i>i module to the receptor analogous to canonical G<i>αβγ</i> heterotrimer. We have demonstrated that the AGS4-G<i>α</i>i complex i ...[more]