Ontology highlight
ABSTRACT:
SUBMITTER: Gnarra JR
PROVIDER: S-EPMC53916 | biostudies-other | 1990 May
REPOSITORIES: biostudies-other
Gnarra J R JR Otani H H Wang M G MG McBride O W OW Sharon M M Leonard W J WJ
Proceedings of the National Academy of Sciences of the United States of America 19900501 9
Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2R alpha chain and the 70-kDa IL-2R beta chain. The low-affinity, IL-2R alpha chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2R beta receptor. We report here identification of the genomic locus for IL-2R beta. The ex ...[more]