Ontology highlight
ABSTRACT:
SUBMITTER: Smith E
PROVIDER: S-EPMC5469830 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Smith Eric E Palethorpe Helen M HM Hayden Annette L AL Young Joanne P JP Underwood Timothy J TJ Drew Paul A PA
Scientific reports 20170613 1
Oesophageal adenocarcinoma (OAC) is increasing in incidence and has a poor prognosis. Tumour derived fibroblasts (TDFs) differ functionally from normal fibroblasts (NDFs), and play a pivotal role in cancer. Many of the differences persist through subculture. We measured the DNA methylation profiles of 10 TDFs from OAC with 12 NDF from normal oesophageal mucosa using Infinium HumanMethylation450 Beadchips and found they differed in multidimensional scaling analysis. We identified 4,856 differenti ...[more]