Ontology highlight
ABSTRACT:
SUBMITTER: Bertoncini CW
PROVIDER: S-EPMC547830 | biostudies-other | 2005 Feb
REPOSITORIES: biostudies-other
Bertoncini Carlos W CW Jung Young-Sang YS Fernandez Claudio O CO Hoyer Wolfgang W Griesinger Christian C Jovin Thomas M TM Zweckstetter Markus M
Proceedings of the National Academy of Sciences of the United States of America 20050125 5
In idiopathic Parkinson's disease, intracytoplasmic neuronal inclusions (Lewy bodies) containing aggregates of the protein alpha-synuclein (alphaS) are deposited in the pigmented nuclei of the brainstem. The mechanisms underlying the structural transition of innocuous, presumably natively unfolded, alphaS to neurotoxic forms are largely unknown. Using paramagnetic relaxation enhancement and NMR dipolar couplings, we show that monomeric alphaS assumes conformations that are stabilized by long-ran ...[more]