Ontology highlight
ABSTRACT:
SUBMITTER: Horniblow RD
PROVIDER: S-EPMC5480081 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Horniblow Richard D RD Bedford Matthew M Hollingworth Robert R Evans Sarah S Sutton Emily E Lal Neeraj N Beggs Andrew A Iqbal Tariq H TH Tselepis Chris C
Cancer science 20170602 6
A role for iron in carcinogenesis is supported by evidence that iron metabolism proteins are modulated in cancer progression. To date, however, the expression of iron regulatory protein-2 (IRP2), which is known to regulate several iron metabolism proteins, has not been assessed in colorectal cancer. Expression of IRP2 was assessed by quantitative RT-PCR and immunohistochemistry in human colorectal cancer tissue. By interrogating The Cancer Genome Atlas (TCGA) database, expression of IRP2 and tra ...[more]