Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases.

ABSTRACT: A short while ago, the human genome and microbiome were analysed simultaneously for the first time as a multi-omic approach. The analyses of heterogeneous population cohorts showed that microbiome components were associated with human genome variations. In-depth analysis of these results reveals that the majority of those relationships are between immune pathways and autoimmune disease-associated microbiome components. Thus, it can be hypothesized that autoimmunity may be associated with homeostatic disequilibrium of the human-microbiome interactome. Further analysis of human genome-human microbiome relationships in disease contexts with tailored systems biology approaches may yield insights into disease pathogenesis and prognosis.

SUBMITTER: Gundogdu A 

PROVIDER: S-EPMC5506383 | biostudies-other | 2017 Apr

REPOSITORIES: biostudies-other