Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases.
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ABSTRACT: A short while ago, the human genome and microbiome were analysed simultaneously for the first time as a multi-omic approach. The analyses of heterogeneous population cohorts showed that microbiome components were associated with human genome variations. In-depth analysis of these results reveals that the majority of those relationships are between immune pathways and autoimmune disease-associated microbiome components. Thus, it can be hypothesized that autoimmunity may be associated with homeostatic disequilibrium of the human-microbiome interactome. Further analysis of human genome-human microbiome relationships in disease contexts with tailored systems biology approaches may yield insights into disease pathogenesis and prognosis.
SUBMITTER: Gundogdu A
PROVIDER: S-EPMC5506383 | biostudies-other | 2017 Apr
REPOSITORIES: biostudies-other
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