Ontology highlight
ABSTRACT:
SUBMITTER: Cook PJ
PROVIDER: S-EPMC5508201 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Nature communications 20170711
The widespread application of high-throughput sequencing methods is resulting in the identification of a rapidly growing number of novel gene fusions caused by tumour-specific chromosomal rearrangements, whose oncogenic potential remains unknown. Here we describe a strategy that builds upon recent advances in genome editing and combines ex vivo and in vivo chromosomal engineering to rapidly and effectively interrogate the oncogenic potential of genomic rearrangements identified in human brain ca ...[more]