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Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Processes.

ABSTRACT: Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (SN1 and SN2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations.

SUBMITTER: Fu GC

PROVIDER: S-EPMC5532721 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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