Identification of key regions and residues controlling A? folding and assembly.
Ontology highlight
ABSTRACT:
SUBMITTER: Hayden EY
PROVIDER: S-EPMC5626695 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Publications
Identification of key regions and residues controlling Aβ folding and assembly.
Hayden Eric Y EY Hoi Kimberly K KK Lopez Jasmine J Inayathullah Mohammed M Condron Margaret M MM Teplow David B DB
Scientific reports 20171003 1
Amyloid β-protein (Aβ) assembly is hypothesized to be a seminal neuropathologic event in Alzheimer's disease (AD). We used an unbiased D-amino acid substitution strategy to determine structure-assembly relationships of 76 different Aβ40 and Aβ42 peptides. We determined the effects of the substitutions on peptide oligomerization, secondary structure dynamics, fibril assembly dynamics, and fibril morphology. Our experiments revealed that the assembly of Aβ42 was more sensitive to chiral substituti ...[more]
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