Ontology highlight
ABSTRACT:
SUBMITTER: Schreuder M
PROVIDER: S-EPMC6851895 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Schreuder Mark M Reitsma Pieter H PH Bos Mettine H A MHA
Journal of thrombosis and haemostasis : JTH 20190617 8
Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. In the presence of an anionic phospholipid membrane and calcium ions, factors Va and Xa assemble into the prothrombinase complex. Following formation of the ternary complex with the macromolecular zymogen substrate prothrombin, the latter is rapidly converted into thrombin, the key regulatory enzyme of coagulation. Over the years, multiple binding sites have been identified in fa ...[more]