Ontology highlight
ABSTRACT:
SUBMITTER: Boulos S
PROVIDER: S-EPMC5630322 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Boulos Suliman S Park Min Chul MC Zeibak Marian M Foo Shen Yun SY Jeon Yoon Kyung YK Kim Young Tae YT Motzik Alex A Tshori Sagi S Hamburger Tamar T Kim Sunghoon S Nechushtan Hovav H Razin Ehud E
Oncotarget 20170522 39
It has been shown that various tRNA synthetases exhibit non-canonical activities unrelated to their original role in translation. We have previously described a signal transduction pathway in which serine 207 phosphorylated lysyl-tRNA synthetase (P-s207 LysRS) is released from the cytoplasmic multi-tRNA synthetase complex (MSC) into the nucleus, where it activates the transcription factor MITF in stimulated cultured mast cells and cardiomyocytes. Here we describe a similar transformation of LysR ...[more]