Ontology highlight
ABSTRACT:
SUBMITTER: Riaz N
PROVIDER: S-EPMC5636842 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Riaz Nadeem N Blecua Pedro P Lim Raymond S RS Shen Ronglai R Higginson Daniel S DS Weinhold Nils N Norton Larry L Weigelt Britta B Powell Simon N SN Reis-Filho Jorge S JS
Nature communications 20171011 1
BRCA1 and BRCA2 are involved in homologous recombination (HR) DNA repair and are germ-line cancer pre-disposition genes that result in a syndrome of hereditary breast and ovarian cancer (HBOC). Whether germ-line or somatic alterations in these genes or other members of the HR pathway and if mono- or bi-allelic alterations of HR-related genes have a phenotypic impact on other cancers remains to be fully elucidated. Here, we perform a pan-cancer analysis of The Cancer Genome Atlas (TCGA) data set ...[more]