Ontology highlight
ABSTRACT:
SUBMITTER: Song L
PROVIDER: S-EPMC5680304 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Scientific reports 20171109 1
Cells are capable of rapid replication and performing tasks adaptively and ultra-sensitively and can be considered as cheap "biological-robots". Here we propose to engineer cells for screening biomolecules in parallel and with high sensitivity. Specifically, we place the biomolecule variants (library) on the bacterial phage M13. We then design cells to screen the library based on cell-phage interactions mediated by a specific intracellular signal change caused by the biomolecule of interest. For ...[more]