Ontology highlight
ABSTRACT:
SUBMITTER: Refaey ME
PROVIDER: S-EPMC5685888 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Refaey Mona El ME McGee-Lawrence Meghan E ME Fulzele Sadanand S Kennedy Eileen J EJ Bollag Wendy B WB Elsalanty Mohammed M Zhong Qing Q Ding Ke-Hong KH Bendzunas Nathaniel G NG Shi Xing-Ming XM Xu Jianrui J Hill William D WD Johnson Maribeth H MH Hunter Monte M Pierce Jessica L JL Yu Kanglun K Hamrick Mark W MW Isales Carlos M CM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20170814 11
Age-dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age-associated increase in the generation of reactive oxygen species has been frequently implicated. We previously reported that aromatic amino acids function as antioxidants, are anabolic for bone, and that they may potentially play a protective role in an aging environment. We hypothesized that upon oxidation the aromatic amino aci ...[more]