Ontology highlight
ABSTRACT:
SUBMITTER: Rohrs TM
PROVIDER: S-EPMC5687070 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20170728 36
Re<sub>2</sub> O<sub>7</sub> catalysis effects efficient and stereoselective dehydrative cyclization reactions from monoallylic diols, with stereocontrol arising from thermodynamic equilibration. This method was applied to a rapid synthesis of the spliceosome inhibitor herboxidiene. The route was also utilized for the synthesis of an analogue that highlights the importance of a single methyl group in biasing the conformation in the acyclic region of the molecule. ...[more]