Ontology highlight
ABSTRACT:
SUBMITTER: Suh HN
PROVIDER: S-EPMC5726811 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Suh Han Na HN Kim Moon Jong MJ Jung Youn-Sang YS Lien Esther M EM Jun Sohee S Park Jae-Il JI
Cell reports 20171101 9
Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert<sup>+</sup> intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (Tert<sup>TCE/+</sup>) mouse model, we found that Tert<sup>+</sup> cells are long-term label-retaining self-renewing cells, which are partially distinguished from the previously identified +4 ISCs. Tert<sup>+</sup> cells become mitotic upon irradiation (IR) inju ...[more]